Abstract
A novel pelletizing process, spheronization, was used to prepare spherical particles for use in tablet compression. Dibasic calcium phosphate, acetaminophen, magnesium hydroxide, and sulfadiazine granulations were prepared and compressed into acceptable tablets. Tests showed that the spheronizing process resulted in an improved granulation flow rate and narrow particle-size distribution as compared to a conventionally processed wet granulation. Granulation reproducibility and change of size distribution with processing time were also studied. Tablets were compressed from all granulations, and hardness and disintegration times were determined.
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