Tablet Content Analysis Using Terahertz Transmission Spectroscopy

Abstract

A group of pressed tablets with acetaminophen content between 60 mg and 120 mg were scanned in the terahertz spectral region (2 cm−1–120 cm−1) in transmission mode. Tablet acetaminophen content was determined by a standard HPLC method. Despite the lack of discernible spectral features and the tablets being opaque above 45 cm−1, a working partial least squares model could be constructed. The results show the expected linearity between absorbance and tablet composition in the terahertz range. There were no observable effects on the terahertz spectra due to different tablet compaction force.