Abstract
Serotonin transporter binding studies in major depressive disorder (MDD) report disparate findings. Traditional image analysis approaches use regions of interest not based on serotonin anatomy. Brainstem serotonin neuron cell bodies project to frontal pole before projecting to occipital pole. There is excess serotonin synthesis capacity in the cell bodies in MDD and deficient serotonin transmission in projection areas. We sought to determine if MDD has a serotonin system abnormality that varies with distance along the axon from the cell body.
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