Abstract
BackgroundSaccadic (ocular motor) deficits are one of the most replicated findings in schizophrenia. However, less research has been conducted investigating the broader schizophrenia continuum. Recent research suggests that the personality characteristics and symptoms observed in schizophrenia lie on a continuum with subclinical symptoms, known as schizotypy, observed in the non-clinical population. Schizotypy is considered a suitable model for investigating schizophrenia as it mirrors the symptoms, albeit in a more subtle manner. As saccadic deficits are a cognitive hallmark of schizophrenia, it is believed that saccadic deficit may be associated with higher schizotypy. The aim of the current study was to 1) replicate previous findings of impairments in antisaccade and memory-guided saccade performance in schizophrenia and 2) investigate the relationship between antisaccade and memory-guided saccade performance and schizotypy.Methods105 adults (35 patients with schizophrenia/schizoaffective disorder and 70 healthy controls) completed the antisaccade and memory-guided saccade tasks, which engage spatial working memory and inhibition processes. The variables analysed for both saccade paradigms were error rate, latency (ie. reaction time) and gain (ie. spatial accuracy). Schizotypy was assessed using the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE), a 104 item questionnaire which measures the three main schizotypy factors: Unusual Experiences, Introvertive Anhedonia and Cognitive Disorganisation. A total O-LIFE score was also calculated from these three schizotypy factors as a representation of global schizotypy. Controls were then divided into low (n = 35) and high schizotypy groups (n = 35). A MANOVA was conducted to observe differences in eye movement variables between low schizotypy individuals, high schizotypy individuals and patients. Correlations were also conducted to further investigate these relationships.ResultsAntisaccade error rate, (p < 0.001), antisaccade latency (p = 0.007), memory-guided saccade error rate (p = 0.009) and latency (p < 0.001) were significantly different between patients and controls. When comparing low schizotypy, high schizotypy and patient groups, the MANOVA revealed significant differences for antisaccade and memory-guided saccade latency and a non-significant trend for antisaccade gain. However, post-hoc analyses revealed that there was only a significant difference between low schizotypy and patient groups (p < 0.001), but not between low schizotypy and high schizotypy nor between high schizotypy and patient. Looking across the schizophrenia continuum, there were significant correlations between the total O-LIFE score and antisaccade gain (p = 0.033), memory-guided saccade latency (p = 0.014) and memory-guided saccade gain (p = 0.011). A non-significant trend was also observed between the total O-LIFE score and antisaccade latency (p = 0.088).DiscussionThis study replicated previous findings of impaired saccade performance in schizophrenia. In addition, it also replicated findings of impaired antisaccade performance in higher schizotypy and is the first study to investigate and demonstrate the relationship between higher schizotypy and impaired memory-guided saccade performance. Overall, these findings supporting the use of schizotypy as a model for schizophrenia and also support the theory of schizotypy and a broader schizophrenia continuum.
Highlights
Health literacy (HL) has been defined as the degree to which individuals possess the capacity to obtain, process, understand and utilise basic health information
People living in the community, and attending public community mental health outpatient clinics in the Northern suburbs of Adelaide, Australia, were invited to participate in the study. They were interviewed by trained research staff, and completed the WAIS VI digit symbol coding (DSC), Verbal Fluency (VF; animal naming), the short version of the Test of Functional Health Literacy in Adults (S-TOFHLA) along with two parts of the Woodcock-Johnson III measuring aural literacy (Part 4; WJ4) and reading literacy (Part 9; WJ9)
As saccadic deficits are a Abstracts for the Sixth Biennial SIRS Conference cognitive hallmark of schizophrenia, it is believed that saccadic deficit may be associated with higher schizotypy
Summary
Semantic memory (memory for facts, concepts, and knowledge of the external world) abnormalities are predicted to underlie disturbances in thought and language, deficits in cognitive domains, and the development and maintenance of delusions in patients with schizophrenia. Electroencephalographic (EEG) recordings have successfully identified the neural time course for the processing of semantic information as an electrophysiological response between 300 and 500ms post stimulus (i.e., the N400). The N400 is a remarkably consistent and highly sensitive neural response to semantic relationships, and is thought to index the binding of current stimuli into context by detecting whether meaning is shared with recently processed stimuli or items in memory. The N400 appears to be amodal: an index of semantic processing irrespective of stimulus type (e.g., word/picture stimuli alike), and has shown mixed findings in schizophrenia. Existing literature has largely relied on EEG or functional magnetic resonance imaging (fMRI) techniques, and these are constrained in spatial and temporal resolution, respectively. MEG provides excellent spatio-temporal resolution, not possible from other stand-alone neuroimaging techniques. We aimed to determine the neuromagnetic correlates of novel semantic triads in both lexical and picture form, and to determine N400m differences in high/ low schizotypal samples
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
