T6 Therapeutically targeting PTBP1/PKM2-driven glycolysis in endothelial cells: a novel approach to treat pulmonary arterial hypertension

Abstract

BackgroundPulmonary Arterial Hypertension (PAH) is an often-fatal disease, characterised by the development of apoptosis-resistant, hyperproliferative, and hyper-glycolytic endothelial cells (ECs). Loss-of-function BMPR2 mutations and metabolic dysfunction are pivotal to PAH...