Abstract
T3P is a highly reactive n-propyl phosphonic acid cyclic anhydride (II, Scheme 1) originally designed as a coupling agent. [1] T3P works both as coupling and as water removal reagent, offering several advantages over traditional reagents, such as high yields and purity, low toxicity, broad functional group tolerance, low epimerization tendency without any additives, and easy work-up (only water-soluble by-products, eliminating the need of chromatographic columns). [1] [2] It can be prepared from the reaction of propyl phosphonic acid (I, Scheme 1) with acetic anhydride at a temperature preferably in the range of 70-110 °C; then the oligomeric phosphonic acid anhydride intermediate is distilled at 0.01-50 mbar and a temperature range of 200-350 °C. The cyclic anhydride II is immediately dissolved in an inert organic solvent. [3] [4]
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