Abstract

Deep brain stimulation (DBS) technologies have attracted increasing interest in the treatment of psychiatric disease due to growing evidence of disrupted brain circuits and connectivity in several psychopathologies. Animal models of DBS would be helpful, but to mimic human DBS, those stimulators should not require bulky, limiting tethers. We aimed to validate a novel wireless neurostimulator device, the e-Particle (EP), using rewarding medial forebrain bundle (MFB) stimulation in a conditioned place preference (CPP) paradigm.

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