Abstract
Sensorimotor gating of startle measured by prepulse inhibition (PPI) is regulated by prefrontal cortex (PFC) and ventral striatal dopamine. Tolcapone, a reversible catechol-O-methyl transferase (COMT) inhibitor, increases PFC dopamine tone. Previous studies in Greek conscripts reported that tolcapone increased PPI in men homozygous for the valine allele at the COMT polymorphism, rs4680. We previously reported pro-cognitive effects of tolcapone in healthy adults; here we report the effects of tolcapone on PPI in these subjects.
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