T2 values of the acutely infarcted myocardium following primary PCI: the relationship with infarct characteristics and gadolinium extracellular volume of distribution

Elisa Mcalindon,Chris B Lawton,Nauman Ahmed,Tom Johnson,Chiara Bucciarelli-Ducci,Julian Strange,Amardeep Ghosh Dastidar,Andreas Baumbach

doi:10.1186/1532-429x-17-s1-p138

Abstract

Background T2 mapping has been shown to detect myocardial oedema as assessed by histology in animals, and is a promising sequence to detect the area at risk in STEMI. The specific cut off value to identify abnormal myocardium in STEMI has not been identified nor have the effects of infarct characteristics on T2 valves. The extra cellular volume fraction (ECV) has been validated against histology in humans. The aims of this study were to identify a cut-off T2 for prediction of myocardial oedema following acute reperfused myocardial infarction and determine if infarct characteristics affect T2 values. In addition, this study aims to determine if T2 values are associated with the ECV following STEMI. Methods 50 consecutive patients presenting with STEMI to the Bristol Heart Institute Primary PCI service were approached for inclusion in the study. Patients had a CMR scan day 2 following STEMI. T2 values were assessed by T2 mapping. The myocardium was divided according to the AHA segments. Regional wall motion, LGE transmurality, presence of persistent microvascular obstruction (PMVO) and T2 values were assessed per segment. Segments were deemed affected if they did not have normal wall motion. In addition, a further 30 patients had a CMR day 2 following STEMI. Pre-contrast T1, T2 valves were assessed. Post contrast T1 was measured at 25 minutes following contrast administration. ECV was calculated as:

Highlights

T2 mapping has been shown to detect myocardial oedema as assessed by histology in animals, and is a promising sequence to detect the area at risk in STEMI
A T2 value of 55ms most optimally differentiated the segments with regional wall motion abnormalities from those segments with a normal systolic function, with a sensitivity of 0.79 and a 1-specificity of 0.33 (AUC 0.802, p
T2 values differ depending on the transmurality of the LGE per segment: LGE 1 (0-25%) median 56.6ms, IQR 53.9-60.1ms; LGE 2 (25-50%) median 60.1ms, IQR 55.0-67.0ms; LGE 3 (50-75%) median 63.7ms, IQR 60.3ms-69.4ms; LGE 4 (75-100%) median 64.7 ms, IQR 60.0-69.8ms p

Summary

Introduction

T2 mapping has been shown to detect myocardial oedema as assessed by histology in animals, and is a promising sequence to detect the area at risk in STEMI. The specific cut off value to identify abnormal myocardium in STEMI has not been identified nor have the effects of infarct characteristics on T2 valves. The extra cellular volume fraction (ECV) has been validated against histology in humans. The aims of this study were to identify a cut-off T2 for prediction of myocardial oedema following acute reperfused myocardial infarction and determine if infarct characteristics affect T2 values. This study aims to determine if T2 values are associated with the ECV following STEMI

Objectives

Methods

Results