Abstract
G A A b st ra ct s cell migration was reduced in TSC2(-/-) rat embryonic fibroblast (REF) cells. In addition, an increase of actin stress fiber formation was observed in TSC2(-/-) REF cells upon stimulation with IGF-1. Furthermore, we showed that the activation of Rac-GTPase was largely impaired in both TSC2(-/-) REF and TSC2 knockdown cancer cells, suggesting that maintaining TSC2 expression is required for Rac activation and cell migration. Our results are consistent with the fact that patients with TSC2 mutations only develop benign and nonmetastatic tumors. Collectively, we identified a novel role of TSC2 in controlling cell motility and cytoskeleton rearrangement by regulating Rac activation.
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