Abstract
T182. GABA and Glutamate in Patients With 22q11.2 Deletion Syndrome and Healthy Volunteers and the Relation With Cognition: A Randomized Double-Blind 7Tesla Pharmacological MRS Study
Highlights
Structural volume loss of cortical gray matter over time in schizophrenia has been widely reported (Vita et al 2012), and may be more pronounced when the disorder has an onset prior to age 18 (Early Onset Psychosis, EOP; Arango et al 2008)
Patients with EOP were recruited at first episode, matched by sex and age with healthy controls (HC) and re-assessed at 10 years
Our results have identified: 1) thinner cortices in frontal regions in EOP compared to Healthy controls (HC), which seems to be constant over time; and 2) a decreased in SA in frontal areas in EOP along time, contrasting with HC, whose frontal surface increased at follow-up
Summary
Identification of biomarkers of transition to psychosis in individuals at ultra-high risk (UHR) has the potential to improve future outcomes (McGorry, 2008). Structural MRI studies with UHR samples have revealed steeper rates of cortical thinning in temporal, prefrontal and cingulate cortices in individuals who later develop psychosis in both baseline and longitudinal comparisons (Fusar-Poli, 2011; Cannon, 2014). No significant differences in global CTH in UHR-P (2.57 ± 0.13mm) relative to UHR-NP (2.56 ± 0.11mm) and HC (2.58 ± 0.09mm) were found. There was a significant group effect on the right cingulate cortex (F=6.6, pFDR=.024): UHR-P showed lower CTH in this area relative to controls (p=.007 uncorrected). Within the right cingulate cortex, a significant group effect was found in the posterior cingulate (F=5.7, pFDR=.016) and isthmus (F=4.6, pFDR=.024), and a trend level in the caudal anterior cingulate (F=2.9, p=.057): with smaller CTH in UHR-P relative to HC in the isthmus cingulate (p=.025) and the posterior cingulate (p=.066). No significant differences were observed between UHR-P and UHR-NP groups
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