T125. Blood Metabolomics Analysis Identifies Abnormalities in the Glycolytic System and Tricarboxylic Acid Cycle in Bipolar Disorder

Abstract

Although offspring of bipolar parents present a fourfold increased risk of developing Bipolar Disorder (BD) compared to offspring of healthy parents, the precise biological mechanisms underlying this increased risk remains unknown. In this study, we performed a metabolomics analyses to quantify plasma levels of 15 metabolites from the glycolysis and tricarboxylic acid (TCA) cycle from children and adolescents BD patients, unaffected offspring of BD parents, affected offspring of BD parents and healthy controls (HCs).