Abstract
We present an ultrahigh resolution in vivo human brain magnetic resonance imaging (MRI) dataset. It consists of T1-weighted whole brain anatomical data acquired at 7 Tesla with a nominal isotropic resolution of 250 μm of a single young healthy Caucasian subject and was recorded using prospective motion correction. The raw data amounts to approximately 1.2 TB and was acquired in eight hours total scan time. The resolution of this dataset is far beyond any previously published in vivo structural whole brain dataset. Its potential use is to build an in vivo MR brain atlas. Methods for image reconstruction and image restoration can be improved as the raw data is made available. Pre-processing and segmentation procedures can possibly be enhanced for high magnetic field strength and ultrahigh resolution data. Furthermore, potential resolution induced changes in quantitative data analysis can be assessed, e.g., cortical thickness or volumetric measures, as high quality images with an isotropic resolution of 1 and 0.5 mm of the same subject are included in the repository as well.
Highlights
Background & SummaryBridging gaps between optical microscopy of histological specimens and non-invasive in vivo imaging is one major goal of ultrahigh field magnetic resonance imaging
High spatial resolution imaging with sufficient signal-to-noise ratio (SNR) leads to prolonged time of acquisition
Even well-versed subjects tend to move a few millimeters during an hour of scan time, limiting the effective resolution for in vivo imaging
Summary
Background & SummaryBridging gaps between optical microscopy of histological specimens and non-invasive in vivo imaging is one major goal of ultrahigh field magnetic resonance imaging. Our imaging protocol has been motivated by the goal to acquire T1-weighted whole brain anatomical data with a nominal isotropic resolution of 250 μm, maximized SNR, and a tolerable scan time of one hour per volume (Table 1). To achieve acceptable SNR we used a 7 T MR system and acquired eight T1-weighted volumes of a single young healthy Caucasian subject using prospective motion correction.
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