T07-P-04 Impact of vardenafil on blood pressure of hypertensive impotent males

Abstract

Objective It is very well known that the use of vardenafil could be lethal if it is combined with cardiovascular agents as nitrates. The aim of the study was to evaluate the impact of vardenafil on blood pressure of hypertensive impotent males. Design and method 30 impotent patients were included in the study. All of them received antihypertensive treatment. They were asked to receive vardenafil 20mg on a Sunday morning and to measure their blood pressure immediately after and every three hours until midnight (totally 6 measurements). The patients could follow a normal day activity even make sex. The results were compared with the previous day measurements of blood pressure (totally 3 measurements). Results The mean age of the patients was 61,5 years (46-74) The repeated measurements showed that the mean blood pressure was significant lower after vardenafil. Individual blood pressure profiles revealed 23 of 30 patients (76%) experienced blood pressure dro P >15mmHg during the 12 hours post intake. 3 (10%) patients experienced at least one dro P >30mmHg. There were no significantly changes of heart rate. All the patients were asymptomatic despite the changes of blood pressure or heart rate. Conclusions The results showed that vardenafil has significant impact on decreasing blood pressure. Although more data is required, this study suggest that physicians should be very careful when prescribe vardenafil to individuals at risk for cardiovascular side effects.