Abstract
Summary The effect of increasing doses of rt-PA (Alteplase) in catheter related thrombi in children was studied. The data suggest that optimal local fibrinolytic treatment is realized at a systemic level of 0.80 ng/ml of t-PA, which was reached with a dosis of 0.10 mg/kg·hour directly infused via the affected catheter. After the introduction of rt-PA the level of PAI-1 activity immediately fell below 2 IU/ml, whereas the amount of PAI-1 antigen stayed at the same level throughout rt-PA treatment.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
