Abstract
We report phenotypic and functional characterization of lymph node cells from 27 patients with T lymphoma from the Nagasaki district of Japan. Nagasaki is one of several areas where adult T-cell leukemia is endemic, and sera from 18 of 23 patients examined (78.3%) were positive for antibody to adult T-cell leukemia-associated antigen. The majority of cases (24 of 27) showed the Leu-2a −, 3a +, MASO36c − phenotype similar to adult T-cell leukemia, but seemed to be subdivived into four groups according to the presence or absence of Leu-1 antigen and the receptor for sheep erythrocytes (SRBC). Eleven cases had both Leu-1 antigen and the receptor for SRBC (E-RFC +, Leu-1 +, 2a −, 3a +), but 6 cases lacked Leu-1 antigen (E-RFC +, Leu-1 −, 2a −, 3a +), 4 cases lacked receptors for SRBC (E-RFC −, Leu-1 +, 2a −, 3a +), and 3 cases lacked both of these markers (E-RFC −, Leu-1 −, 2a −, 3a +). The effects of lymph node T cells on pokeweed mitogen (PWM)-induced normal B-cell differentiation was studied in 10 cases. Lymph node T cells of 5 cases showed helper activity without any suppressor activity, and 2 cases showed suppressor activity with almost no detectable helper activity, similar to adult T-cell leukemia cells. Two other cases lacked particular functional effects. These results suggest the possibility that Leu-3a + T-cell lymphoma may be functionally subdivided into at least two types, a helper type and a suppressor (adult T-cell leukemia) type.
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