Abstract
T Lymphocyte Plasticity in Autoimmunity and Cancer.
Highlights
In this special issue, authors addressed topics related to the altered frequencies and functions of T lymphocyte subsets and the molecular and cellular mechanisms responsible for T cell lineage commitment, polarization, and reprogrammed adaptive responses in health and pathology
Among numerous immune suppressive mechanisms employed by cancer, BioMed Research International the deprivation of adenosine triphosphate (ATP) plays an important role as ATP is essential for T cell activation
Extracellular ATP concentration is maintained by the ectonucleotidase CD39 which is involved in the suppression of T lymphocyte activation by CD11c+ dendritic cells infiltrating tumors in the mouse lung LLC and mammary 4T1 cancer models, as described by M
Summary
Authors addressed topics related to the altered frequencies and functions of T lymphocyte subsets and the molecular and cellular mechanisms responsible for T cell lineage commitment, polarization, and reprogrammed adaptive responses in health and pathology. T lymphocytes are essential for the development and regulation of adaptive immune responses. Upon engagement of their specific antigen receptor in presence of appropriate costimulatory signals and specific cytokines, naıve CD4+ and CD8+ T cells differentiate into specific effector or suppressor subsets exhibiting distinct phenotypic characteristics and functions.
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