Abstract
MAREK'S disease (MD) is a contagious lymphoproliferative condition of chickens caused by a herpesvirus. It has the distinction of being the first commonly occurring tumour to be controlled by vaccination. In its complex pathology and aetiology the disease bears remarkable similarities to Burkitt's lymphoma (BL), but the potential of MD as a model of human lymphoproliferative disease and of herpesvirus-induced neoplasia has not been fully realised. One obstacle has been the lack of any established cell lines1. This contrasts with studies on BL, where, in the absence of suitable experimental animals, attention has been focused on the growth of tumour cells in vitro2. A continuous cell culture from a lymphoma of MD has recently, however, been reported3. We now report the establishment of two cell lines from MD lymphomas and their characterisation as T cells.
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