Abstract
Objective The objectives of this study was to analyze the peripheral blood T-lymphocyte subsets of the Th1-related versus Th2-related cytokines of CD4 + cells, and the Tc1 versus Tc2 cytokines of CD8 + cells liver transplant recipients with versus without active cytomegalovirus (CMV) infection. Methods Isolated peripheral blood mononuclear cells (PBMC) were stimulated using PMA/Ionomycin/Monensin. Interleukin (IL)-4 and interferon gamma (IFN-γ) production by CD4 + and CD8 +T cells were determined using fluorescence-activated cell sorter (FACS) analysis. Results The ratios of CD4/CD8 were significantly lower among active CMV-infected patients. The levels of Th2 and Tc2 cytokines (IL-4) were similar between CMV-infected and uninfected patients. However, the levels of Th1-type and Tc1-type cytokines (IFN-r) were significantly lower among active CMV-infected patients. Conclusions Low levels of Th1-type cytokines seem to correlate with active CMV infection in liver transplant recipients.
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