Abstract
Th17 cells that derive from initial T cells are a newly discovered class of CD4+ T cells different from Th1 and Th2 cells. They secrete interleukin (IL)-17, IL-6, IL-22, tumor necrosis factor and other cytokines, and play an important role in mediating chronic inflammation, autoimmune diseases, etc. Recent studies have evidenced that IL-17 posseses a potent anti-HIV activity and exerts a crucial role in anti-HIV cytokine regulatory networks. In early HIV infection, there is a significant reduction or depletion of Th17 cells in peripheral blood and gastrointestinal tract. Nevertheless, further exploration is required to clarify the antiviral function of Th17 cells. Studies have evidenced that the first target of HIV virus attacks is CCR5+CCR6+Th17 cells. As a new target of HIV, Th17 cells are expected to provide new therapeutic strategy for AIDS treatment. Key words: Th17 cells; HIV; Infection
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