Abstract
Ichthyoses are heterogeneous genetic skin diseases that are characterized by thickened and desquamating skin. Causative genes are associated with stratum corneum (SC) formation. The two most common ichthyoses are ichthyosis vulgaris and recessive X-linked ichthyosis. Ichthyosis vulgaris is caused by gene variants in FLG encoding FLG (Oji et al., 2010), and it is known to increase the risk of developing atopic dermatitis (AD). Recessive X-linked ichthyosis results from variants in STS. STS encodes steroid sulfatase, and STS abnormalities lead to the accumulation of cholesterol sulfate and result in corneocyte retention (Oji et al., 2010).
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