Abstract
T and B cell cooperation normally takes place in secondary lymphoid organs (SLO). However, both cell types are also frequently found in inflamed non-lymphoid tissues. Under certain conditions, these infiltrates develop into ectopic lymphoid structures, also known as tertiary lymphoid tissues, which structurally and functionally fully resemble germinal centers (GCs) in SLO. However, tertiary lymphoid tissue is uncommon in most human autoimmune conditions; instead, relatively unstructured T and B cell infiltrates are found. Recent studies have demonstrated that active T and B cell cooperation can also take place in such unstructured aggregates. The infiltrating cells contain a population of T follicular helper (Tfh)-like cells (also designated “peripheral T helper cells”) lacking prototypic Tfh markers like CXCR5 and Bcl-6 but nevertheless expressing high levels of molecules important for B cell help like IL-21 and CD40L. Moreover, Tfh-like cells isolated from inflamed tissues can drive the differentiation of B cells into antibody-secreting cells in vitro. These findings are not restricted to experimental animal models but have been reproduced in rheumatoid arthritis and breast cancer patients. At this point, it is unclear whether T and B cell cooperation outside the ordered structure of the GC fully mirrors the reactions in SLO. However, Tfh-like cells in inflamed tissues are certainly important for the local differentiation of B cells into antibody-secreting cells, and should be considered as an important target for the treatment of autoimmune diseases.
Highlights
The successful interaction of antigen-specific T and B cells is key to an effective humoral immune response resulting in the generation of high-affinity antibodies and long-term memory B cells
There, in the germinal center (GC) reaction, T follicular helper (Tfh) cells interact with antigen-specific B cells and drive their affinity maturation and further differentiation by means of the expression of CD40L and IL-21
Two more recent studies analyzing larger numbers of samples and more specific parameters came to the conclusion that fully developed, follicular dendritic cells (FDC)-positive ECTOPIC LYMPHOID STRUCTURES (ELS) are rather rare in synovial tissue from arthritis patients with a prevalence of only 6–8% [15, 16]
Summary
The successful interaction of antigen-specific T and B cells is key to an effective humoral immune response resulting in the generation of high-affinity antibodies and long-term memory B cells. In rheumatoid arthritis patients, where ELS were first described in the synovial membrane of inflamed joints, early studies reported an incidence of fully developed, FDC-containing, and thereby GC-like infiltrates of approximately 25% [12,13,14].
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.