Abstract
Meeting abstracts Dendritic cell-tumor cell hybrids (heterokaryons) are under investigation as a means for tumor immunotherapy since they should express MHC class I molecules from both cell types and, thus, present tumor antigens within an immunogenic context. The aim of this work was, therefore,
Highlights
T cell stimulation by dendritic cell-tumor cell hybrids is enhanced in the presence of free dendritic cells
Dendritic cell-tumor cell hybrids are under investigation as a means for tumor immunotherapy since they should express MHC class I molecules from both cell types and, present tumor antigens within an immunogenic context
Mature dendritic cells differentiated from peripheral blood of healthy donors were fused with cells from the breast cancer cell line MDA-MB-231 by applying an electric pulse
Summary
Dendritic cell-tumor cell hybrids (heterokaryons) are under investigation as a means for tumor immunotherapy since they should express MHC class I molecules from both cell types and, present tumor antigens within an immunogenic context. T cell stimulation by dendritic cell-tumor cell hybrids is enhanced in the presence of free dendritic cells Mariana P Pinho*, Patricia C Bergami-Santos, José Alexandre M Barbuto
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