T-cell redirection therapy after allogeneic stem cell transplantation in multiple myeloma: When the cure fails!

Abstract

Allogeneic stem cell transplant remains an option for patients with myeloma. Given the unfortunate inevitability of the majority of patients, relapsing salvage therapy options are needed. Although there is a potential concern for subsequent T-cell redirection therapy in these patients, Hammons etal. provide a retrospective look at patients treated this way with no new significant adverse safety or efficacy signal. Commentary on: Hammons etal. Chimeric antigen receptor and bispecific T-cell engager therapies in multiple myeloma patients with prior allogeneic transplantation. Br J Haematol 2024;204:887-891.