T-Cell Receptor Analysis for Diagnosing CTCL

Abstract

The diagnosis of cutaneous T-cell lymphoma (CTCL) can be difficult early in the course of the disease. Routine histologic biopsy specimens often show subtle or nonspecific changes. Lymphocyte immunophenotyping is sometimes helpful, but the results are often ambiguous. Recently, T-cell gene rearrangement analysis was touted as helpful in diagnosing these early lesions. In the present study, the authors performed T-cell gene rearrangement …