Abstract
IRF5 polymorphisms are associated with multiple immune-mediated diseases, including ulcerative colitis. IRF5 contributions are attributed to its role in myeloid lineages. How Tcell-intrinsic IRF5 contributes to inflammatory outcomes is not well understood. We identify a previously undefined key role for Tcell-intrinsic IRF5. In mice, IRF5 in CD4+ Tcells promotes Th1- and Th17-associated cytokines and decreases Th2-associated cytokines. IRF5 is required for the optimal assembly of the TCR-initiated signaling complex and downstream signaling at early times, and at later times binds to promoters of Th1- and Th17-associated transcription factors and cytokines. IRF5 also regulates chemokine receptor-initiated signaling and, in turn, Tcell migration. Invivo, IRF5 in CD4+ Tcells enhances the severity of experimental colitis. Importantly, human CD4+ Tcells from high IRF5-expressing disease-risk genetic carriers demonstrate increased chemokine-induced migration and Th1/Th17 cytokines and reduced Th2-associated and anti-inflammatory cytokines. These data demonstrate key roles for Tcell-intrinsic IRF5 in inflammatory outcomes.
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