Abstract

Splenomegaly is a frequent yet challenging condition that clinicians have to deal within their daily clinical practice. Although the spleen is commonly involved in disseminated lymphoma, primary lymphoma of the spleen is rare. A great majority of the reported cases are of B-cell lineage, with diffuse large B-cell lymphoma being the most common. A new variant of T-cell/histiocyte-rich B-cell was first described by Dogan et al. in 2003.1 The combined morphologic, immunohistochemical, and molecular genetic data are essential for a correct diagnosis of splenic T-cell-rich B-cell lymphoma. We report a classical case of T-cell-rich B-cell lymphoma of the spleen in a 45-year-old male patient with clinical diagnosis of splenomegaly.

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