Abstract
DCs often require stimulation from CD4(+) Tcells to propagate CD8(+) Tcell responses, but precisely how Tcell help optimizes the priming capacity of DCs and why this appears to differ between varying types of CD8(+) Tcell immunity remains unclear. We show that CD8(+) Tcell priming upon HSV-1 skin infection depended on DCs receiving stimulation from both IFN-α/β and CD4(+) Tcells to provide IL-15. This was not an additive effect but resulted from CD4(+) Tcells amplifying DC production of IL-15 in response to IFN-α/β. We also observed that increased innate stimulation reversed the helper dependence of CD8(+) Tcell priming and that the innate stimulus, rather than the CD4(+) Tcells themselves, determined how "help'" was integrated into the priming response by DCs. These findings identify Tcell help as a flexible means to amplify varying suboptimal innate signals in DCs.
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