Abstract

Chronic inflammatory diseases are characterized by a disturbed immune balance leading to recurring episodes of inflammation in specific target tissues, such as the joints in juvenile idiopathic arthritis. The tissue becomes infiltrated by multiple types of immune cell, including high numbers of CD4 and CD8 T-cells, which are mostly effector memory cells. Locally, these T-cells display an environment-adapted phenotype, induced by inflammation- and tissue-specific instructions. Some of the infiltrated T-cells may become tissue resident and play a role in relapses of inflammation. Adaptation to the environment may lead to functional (re)programming of cells and altered cellular interactions and responses. For example, specifically at the site of inflammation both CD4 and CD8 T-cells can become resistant to regulatory T-cell-mediated regulation. In addition, CD8 and CD4 T-cells show a unique profile with pro- and anti-inflammatory features coexisting in the same compartment. Also regulatory T-cells are neither homogeneous nor static in nature and show features of functional differentiation, and plasticity in inflammatory environments. Here we will discuss the recent insights in T-cell functional specialization, regulation, and clonal expansion in local (tissue) inflammation.

Highlights

  • A typical hallmark of immune-mediated inflammatory diseases (IMIDs) is the intermittent presence of inflammation that manifest in specific target tissues

  • In this review we summarize the findings on CD8+, CD4+, and FOXP3+ regulatory T-cell (Treg) subsets in the contexts of local adaptation and functional differentiation

  • The expanding field of T-cells, including the discovery of multiple Th subsets as well as observations of mixed phenotypes in inflamed tissues, has made the classification of subsets increasingly complex [5]. This complexity, likely represents human immunity that is continuously exposed to multiple microorganisms and environmental conditions, in contrast to highly controlled mouse models that have contributed to most of the current knowledge [32, 119]

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Summary

Gerdien Mijnheer and Femke van Wijk*

Laboratory of Translational Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. Chronic inflammatory diseases are characterized by a disturbed immune balance leading to recurring episodes of inflammation in specific target tissues, such as the joints in juvenile idiopathic arthritis. The tissue becomes infiltrated by multiple types of immune cell, including high numbers of CD4 and CD8 T-cells, which are mostly effector memory cells. These T-cells display an environment-adapted phenotype, induced by inflammation- and tissue-specific instructions. Adaptation to the environment may lead to functional (re)programming of cells and altered cellular interactions and responses. Regulatory T-cells are neither homogeneous nor static in nature and show features of functional differentiation, and plasticity in inflammatory environments. We will discuss the recent insights in T-cell functional specialization, regulation, and clonal expansion in local (tissue) inflammation

INTRODUCTION
Findings
CONCLUSION AND FUTURE PERSPECTIVES
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