Abstract
A total of 80 subjects with benign and malignant breast disease and healthy controls were studied for reactivity to T-antigen, MN-antigens and phytohemagglutinin (PHA) using the lymphocyte blastogenesis assay. No differences were detected between controls and patients with benign or malignant breast disease in reactivity to T- and MN-antigens. Moreover, there was no differential response to T- and MN-antigens among patients with breast cancer. PHA reactivity, although similar between groups as a whole, was diminished in patients with advanced carcinoma. These findings indicate that T-antigen fails to induce cell mediated immunity in patients with breast cancer.
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