Abstract
BackgroundLow adiponectin levels are associated with increased insulin resistance (IR) and arterial stiffness in hypertensive patients, but higher adiponectin levels are also found in heart failure patients. This discrepancy has not been fully resolved, but it may be related to the adiponectin gene (ADIPOQ) which regulates adiponectin production. We aimed to investigate whether the relationship between adiponectin and arterial stiffness is associated with ADIPOQ rs1501299 G/T polymorphism in nondiabetic Korean men.MethodsIn nondiabetic men without disease (n = 301), anthropometric parameters, lipid profiles, IR, circulating adiponectin, and brachial-ankle pulse wave velocity (baPWV) were measured. rs1501299 G/T polymorphism was also analyzed.ResultsCirculating adiponectin levels were negatively correlated with baPWV and homeostatic model assessment-IR in the T allele carriers (n = 167), but this correlation was not observed in the GG subjects (n = 134). However, a positive correlation between baPWV and IR was observed in the GG subjects, but not in the T carriers. These patterns were maintained after the adjustment for confounding factors. A stepwise linear regression analysis revealed that circulating adiponectin and systolic blood pressure (BP) were the main influencing factors on baPWV levels in T carriers, but systolic BP, IR and age were the main contributors to increased baPWV levels in the GG subjects.ConclusionsThis study demonstrates that the relationship between circulating adiponectin and arterial stiffness is different according to ADIPOQ rs1501299 G/T polymorphism, and suggests that T allele is more susceptible to the influence of adiponectin on arterial stiffness than GG homozygotes. This information may prove to be useful for personal-based early prevention and management of atherosclerotic risk.
Highlights
Low adiponectin levels are associated with increased insulin resistance (IR) and arterial stiffness in hypertensive patients, but higher adiponectin levels are found in heart failure patients
Relationships between homeostatic model assessment (HOMA)‐IR, adiponectin and brachial-ankle pulse wave velocity (baPWV) in association with adiponectin gene (ADIPOQ) rs1501299 G/T polymorphisms Based on the results shown in Fig. 2, we examined if the relationships between circulating adiponectin, IR and baPWV were different according to the ADIPOQ rs1501299 G/T polymorphism (Fig. 3)
Main contributors to baPWV levels in association with ADIPOQ rs1501299 G/T polymorphism To investigate if the major contributing factors to baPWV levels were different according to ADIPOQ rs1501299 G/T polymorphism, we performed a stepwise linear regression analysis
Summary
Low adiponectin levels are associated with increased insulin resistance (IR) and arterial stiffness in hypertensive patients, but higher adiponectin levels are found in heart failure patients. This discrepancy has not been fully resolved, but it may be related to the adiponectin gene (ADIPOQ) which regulates adiponectin production. Adiponectin, known as Acrp, AdipoQ, and GBP28, is a 247-amino acid peptide that is secreted by adipocytes [5] and aortic endothelial cells [6] and circulates in large amounts (2–30 μg/ mL) in plasma [7] It has multiple functions such as insulin-sensitization, atheroprotection and cancer prevention [8, 9] by binding the adiponectin receptors (AdipoR1 and 2) on the tissues and cells [10].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
