Abstract
AbstractClove (Syzygium aromaticum) is a popular medicinal plant which has been traditionally used in India as spice and medicine to counter various ailments. However, the stress modulatory and antiaging potential of this plant is yet to be characterized. Therefore, the present study evaluates the effect of clove oil (CO) on oxidative stress, lifespan, mobility, and the expression of aging-related proteins using Caenorhabditis elegans model system. The CO (10 ppm) was found to extend mean lifespan in worms by 21.4% (p < 0.001) under normal and by 63% (p < 0.0001) under juglone-induced oxidative stress conditions. The extension of mean lifespan in mev-1 mutant and elevated expression of gst-4 and sod-3 confirmed stress modulatory effects of CO. Additionally, the CO reduced intracellular ROS and Aβ1–42 proteotoxicity. Altogether, the present study unravels the anti-aging and stress modulatory potential of CO and suggests CO as a potential pharmaceutical entity in modulating aging process.
Highlights
Ayurveda, the word derived from Sanskrit itself means “the scripture of longevity”
Clove oil promotes healthy lifespan in C. elegans An increment in aging world population and age-related ailments have sidetracked the aging research towards dietary interventions promoting longevity with maintenance of vitality of later life
The N2 wild-type worms were exposed to different doses of clove oil (CO) (1, 10 and 100 ppm) from early stages of lifespan and maximal lifespan extension of 21.4% (p < 0.0001) was recorded in 10 ppm followed by 14.35% (p < 0.0001) in 100 ppm and 6.99% (p < 0.0001) in 1 ppm (Figure 1(A), Table 1)
Summary
The word derived from Sanskrit itself means “the scripture of longevity”. The practice finds its foundation in holistic view of treatment which cures human diseases all the way through the establishment of equilibrium between elements of human life, the body, the mind, and the soul. Aakanksha Pant has published peer-reviewed articles in the area of aging, stress biology, dietary interventions regulating aging and age associated disorder She has studied human homologous Caenorhabditis elegans model system for deciphering role of various signaling pathway in regulating aging phenomenon. Present study evaluates effect of clove oil on aging and age-related neurodegenerative Alzheimer’s disease using a free living soil nematode Caenorhabditis elegans organism model which shares genetic similarity with human. Popular medicinal and aromatic plant clove (Syzygium Aromaticum) This popular spice has proven efficacy in treating dental problems, inflammation, and neurodegenerative disorders (Adams, Gmünder, & Hamburger, 2007; Chaieb et al, 2007). The present investigation attempts to determine the effects of CO on oxidative stress, lifespan, mobility, neurotoxicity, and the expression of aging-related proteins
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