Abstract
The Au2S/AuAgS‐coated gold nanorods (Au2S/AuAgS/GNRs) are prepared by a facile synthesis method and functionally modified for their biosensing application. In the preparation process, the longitudinal plasmon resonance (LPR) bands of Au2S/AuAgS/GNRs can be changed by controlling the thickness of the chalcogenide layer coated on GNRs. Especially, the LPR band located at 800 nm is obtained for biosensing application in the near‐infrared region. Furthermore, mercaptoundecanoic acid (MUA) and poly(styrenesulfonate) (PSS) are, respectively, used to modify Au2S/AuAgS/GNRs to acquire the functional nanoprobes; that is, MUA‐modified and PSS‐modified Au2S/AuAgS/GNRs and their different chemical reaction mechanisms are studied by the absorption spectrum and ξ‐potential measurement. Then, the functional nanoprobes are incubated with anti‐prostate‐specific antigen (PSA) antibody to detect PSA. The experimental results demonstrate that the functional nanoprobes are sensitive to the target binding of PSA. Therefore, Au2S/AuAgS/GNRs are suitable to form the bioprobes for detection of PSA in early‐phase prostate cancer.
Highlights
Noble metal nanoparticles have attracted more attentions due to their distinct physical and chemical properties, such as the quantum effect, the small size effect, large surface-to-volume ratio, and high surface chemical activity [1, 2]
gold nanorods (GNRs) are commonly characterized by two principal plasmon absorption bands, corresponding to the transverse plasmon resonance (TPR) and the longitudinal plasmon resonance (LPR) modes which are from the oscillation of conduction electrons [8, 9]
We provided a facile way to modulate the localized surface plasmon resonance band of gold nanorods into near-infrared region by coating a chalcogenide layer on the surface of gold nanorods, namely, Au2S/AuAgScoated gold nanorods (Au2S/AuAgS/GNRs)
Summary
Noble metal nanoparticles (mainly Ag, Au, Pd, and Pt) have attracted more attentions due to their distinct physical and chemical properties, such as the quantum effect, the small size effect, large surface-to-volume ratio, and high surface chemical activity [1, 2]. Over the past decade, many groups have focused their researches on the synthesis mechanism, surface functionality, and relative biological application of gold nanorods (GNRs) [8,9,10,11]. It is because the LSPR properties of GNRs are tuned by changing the aspect ratio of the nanorods besides their high optical absorption cross sections and great molar extinction coefficients in ultraviolet-visible region. The LPR band of GNRs is highly sensitive to the refractive index change of surrounding medium, which has been developed into an effective exploiter of biosensors [12,13,14]
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