Abstract
Numerous studies have demonstrated the importance of digestion and gut microbiota in the nutrition and health of dogs. Artificial digestive systems represent a relevant alternative to in vivo assays, in accordance with the Euro-pean 3Rs rules. Today, a dozen static or dynamic in vitro models reproducing one or more parts of the dogs gas-trointestinal tract have been developed, considering the physicochemical, mechanical and/or microbial parameters of the canine digestion. These models make it possible to study in the laboratory the fate of food and veterinary products in the dogs digestive environment, particularly in terms of macronutrient digestibility, micronutrient bioaccessibility, microorganisms’ survival and activity or drugs’ pharmacokinetics. In order to expand their poten-tial, in the near future these models may be coupled with cellular models or adapted to reproduce pathological conditions, such as obesity.
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