Abstract
Systems genetics approach reveals cross-talk between bile acids and intestinal microbes.
Highlights
Bile acids (BAs) are efficiently maintained within the enterohepatic circulation by the actions of several specific transporter systems, i.e., they travel between the liver and the intestinal lumen, where they interact with microbiome
This interaction is 2-fold: bacteria alter BA composition by changing primary species into secondary, more hydrophobic species, while at the same time, BAs have bacteriostatic actions that depend on their structure and on their physicochemical characteristics [3]. In this issue of PLOS Genetics, Kemis and colleagues [4] present a study in which they performed quantitative trait locus (QTL) analyses on the fecal microbiome and plasma as well as cecal BA profiles of a Diversity Outbred (DO) mouse population, a heterogeneous population derived from eight founder strains that individually harbor distinct microbial communities and display different sensitivities to diet-induced metabolic diseases
The present study in mice has demonstrated the power of systems genetics to decipher interactions of host genetics, microbiome, and BA metabolism
Summary
BAs are efficiently maintained within the enterohepatic circulation by the actions of several specific transporter systems, i.e., they travel between the liver and the intestinal lumen, where they interact with microbiome. In this issue of PLOS Genetics, Kemis and colleagues [4] present a study in which they performed quantitative trait locus (QTL) analyses on the fecal microbiome and plasma as well as cecal BA profiles of a Diversity Outbred (DO) mouse population, a heterogeneous population derived from eight founder strains that individually harbor distinct microbial communities and display different sensitivities to diet-induced metabolic diseases.
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