Abstract
A study of the transcriptomic and phenotypic stress responses of the model crustacean Daphnia magna following exposure to ibuprofen shows similarities in its mode of action between vertebrates and invertebrates.
Highlights
Ibuprofen and other nonsteroidal anti-inflammatory drugs have been designed to interrupt eicosanoid metabolism in mammals, but little is known of how they affect nontarget organisms
In stress ecology, a number of Daphnia magna Straus [6,7,8] and other invertebrate [9] microarray reports have been published, but few of these have integrated transcriptome and phenotype to an extent that clarifies the link between these biological levels
We previously identified the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen as having a targeted impact on reproduction in D. magna following chronic exposure [11], making ibuprofen a good model stressor for integrating genomic and higher level phenotypic stress responses
Summary
Ibuprofen and other nonsteroidal anti-inflammatory drugs have been designed to interrupt eicosanoid metabolism in mammals, but little is known of how they affect nontarget organisms. In stress ecology, a number of Daphnia magna Straus [6,7,8] and other invertebrate [9] microarray reports have been published, but few of these have integrated transcriptome and phenotype to an extent that clarifies the link between these biological levels. This may partly be because many environmental and chemical stressors have a very complex MOA and ecophysiological impact [10], which diminishes the feasibility of linking molecular and organismal levels. Eicosanoids act as autocrine or paracrine signallers (local hormones) and are important regulators of reproduction, ion flux, and immunity in both vertebrates and invertebrates [12]
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