Systems Biology for Multiplatform Data Integration: An Overview.

Abstract

In this chapter, we consider some of the concepts behind multiplatform data integration. First, we examine the types of inferences that can be made using methods that integrate data types. Next, we discuss some broad considerations about methodologies. We conclude with the example of joint analyses of germ line genetic variation, gene expression and complex phenotypes. This chapter draws heavily from analyses that integrate datasets for inference on hereditary aspects of cancer susceptibility. However, these concepts should apply more broadly to other domains.