Systemische Therapie einer Acne conglobata mit Isotretinoin bei einem mit Lamotrigin und Valproinsäure eingestellten epileptischen Anfallsleiden

Abstract

A 21-year-old patient with acne conglobata who received lamotrigine and valproic acid for epilepsy was treated with oral isotretinoin 40 mg daily (according to 0.5 mg/kg body weight daily). Serum levels of antiepileptics were checked regularly. Since treatment led to significant improvement after four months, isotretinoin dosage could be reduced to 30 mg daily. Pathological changes of serum levels of antiepileptics could not be observed during the complete treatment period. In severe acne, isotretinoin should be given to patients treated with antiepileptics if potential drug interactions are considered.