Abstract
The Western Canadian Gastrointestinal Cancer Consensus Conference (WCGCCC) convened virtually on 4 November 2021. The WCGCCC is an interactive multi-disciplinary conference attended by health care professionals, including surgical, medical, and radiation oncologists; pathologists; radiologists; and allied health care professionals from across four Western Canadian provinces, British Columbia, Alberta, Saskatchewan, and Manitoba, who are involved in the care of patients with gastrointestinal cancer. They participated in presentation and discussion sessions for the purpose of developing recommendations on the role of systemic therapy and its optimal sequence in patients with resectable metastatic colorectal cancer.
Highlights
Colorectal cancer is one of the most common cancers and is the leading cause of cancer-related death
In the late 1990s, criteria were established for resectability that were based on the number and size of metastases and the need to have a margin of 1 cm or more [7]
Upfront surgery is the preferred approach in patients with resectable colorectal liver metastases (CRLM)
Summary
Colorectal cancer is one of the most common cancers and is the leading cause of cancer-related death. The liver is the most common site of metastatic disease from colorectal cancer. 50% of patients with colon cancer will present with or develop liver metastasis [1]. 25% of colorectal liver metastases (CRLM) are deemed resectable, and surgery offers the best chance of a cure, improving 5-year survival rates by up to 40–50% [2–4]. Adjuvant systemic therapy in early-stage colon cancer has demonstrated a reduction in the risk of relapse and increased long-term survival, the benefit of chemotherapy in the curative-intent surgical management of patients with resectable CRLM is less clear.
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