Abstract
Quinolones represent a popular group of antibiotics that is favored by physicians due to their potency, broad-spectrum, unique mechanism of action, and reasonable safety. Concerns have been raised about a possible association between quinolones and retinal detachment (RD). Despite the emergence of resistance and availability of other treatment alternatives, quinolones remain a popular choice among physicians worldwide.
Highlights
Quinolones represent a popular group of antibiotics that is favored by physicians due to their potency, broad-spectrum, unique mechanism of action, and reasonable safety
Whereas quinolones are generally considered as having a reasonable safety profile, with most adverse reactions being mild to moderate and self-limiting, some quinolones have been withdrawn from the market and others have sustained restricted
The present review focuses on the occurrence of retinal detachment within thirty days following the administration of a single systemically administered quinolone antibiotic
Summary
Quinolones represent a popular group of antibiotics that is favored by physicians due to their potency, broad-spectrum, unique mechanism of action, and reasonable safety. Areas covered: This systematic review examined all original clinical trials in which a quinolone antibiotic was tested or used as a comparator, for evidence on occurrences of retinal detachment. A number of studies reported ocular adverse reactions in association with use of quinolone antibiotics, including retinal hemorrhage [11], macular degeneration [12], corneal perforation [13], and optic neuropathy [14]. These adverse reactions were reported in association with either systemic or topical quinolone formulations
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