Abstract
Can people genetically unable to synthesize a protein use it if injected? Specifically, can injection of type VII collagen (C-VII) help patients with recessive dystrophic epidermolysis bullosa (RDEB) who lack this protein? Previously, these researchers injected C-VII in a mouse model of RDEB, where, perhaps surprisingly, it was promptly incorporated into the basement membrane zone. Injections into human, organotypic, constructed RDEB-equivalent skin lacking C-VII that had been transplanted onto immunocompromised mice were similarly successful. …
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