Abstract
Oxidative stress biomarkers have been observed in peripheral blood of chronic periodontitis patients; however, their associations with periodontitis were not consistent. This meta-analysis was performed to clarify the associations between chronic periodontitis and oxidative biomarkers in systemic circulation. Electronic searches of PubMed and Embase databases were performed until October 2014 and articles were selected to meet inclusion criteria. Data of oxidative biomarkers levels in peripheral blood of periodontitis patients and periodontal healthy controls were extracted to calculate standardized mean differences (SMDs) and 95% confidence intervals (CIs) by using random-effects model. Of 31 eligible articles, 16 articles with available data were included in meta-analysis. Our results showed that periodontitis patients had significantly lower levels of total antioxidant capacity (SMD = −2.02; 95% CI: −3.08, −0.96; P = 0.000) and higher levels of malondialdehyde (SMD = 0.99; 95% CI: 0.12, 1.86; P = 0.026) and nitric oxide (SMD = 4.98; 95% CI: 2.33, 7.63; P = 0.000) than periodontal healthy control. Superoxide dismutase levels between two groups were not significantly different (SMD = −1.72; 95% CI: −3.50, 0.07; P = 0.059). In conclusion, our meta-analysis showed that chronic periodontitis is significantly associated with circulating levels of three oxidative stress biomarkers, indicating a role of chronic periodontitis in systemic diseases.
Highlights
Chronic periodontitis, characterized by inflammation and destruction of periodontal supporting tissues, is one of the most common oral diseases worldwide
The inclusion criteria were as follows: (1) study subjects were human adults; (2) 7.both periodontitis patients group and periodontal healthy control group were included in the study; (3) at least one oxidative stress biomarker was measured in peripheral blood samples; (4) language was English
Inclusion criteria: 1. study subjects were human adults; 2. both periodontitis patients group and periodontal healthy control group were included in the study 3. at least one oxidative stress biomarker was measured in peripheral blood. 4. language was English
Summary
Chronic periodontitis, characterized by inflammation and destruction of periodontal supporting tissues, is one of the most common oral diseases worldwide. Chronic periodontitis is initially caused by various hyperresponsive and destructive products of immune response stimulated by microbial plaque around the gingival margin. There is some suggestive evidence that periodontal inflammation might be associated with systemic oxidative stress. Abundant evidence has shown that periodontal diseases were highly associated with several inflammation-related systemic diseases, such as chronic respiratory diseases [5], cardiovascular disease [6], and diabetes mellitus [7]. Oxidative stress plays an important role in the pathogenesis of these diseases [8,9,10,11]. It has been hypothesized that oxidative stress arising from periodontal lesions may be an important cause of systemic inflammation. Some but not all epidemiological studies have shown that biomarkers levels of oxidative stress in the peripheral blood of periodontitis patients were different from periodontal
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