Systemic or intra-accumbens injection of D-amphetamine delays habituation to a tone stimulus in rats

Abstract

Dopamine release within the nucleus accumbens shell is suggested to control the salience of environmental stimuli, and previous research has shown that the indirect dopamine agonist D-amphetamine can alter the salience of both aversive and neutral stimuli. In experiment 1, the effect of systemic injection of D-amphetamine (0.5, 1 mg/kg) on fear conditioning to a tone was assessed in an 'off-baseline' conditioned suppression procedure using several footshock intensities. Although the effects of amphetamine on conditioning were unclear, the results indicated a deficit of simple tone habituation in amphetamine-treated rats. In experiment 2, habituation of the orienting reaction to a tone was assessed by the progressive reduction of lick suppression upon repeated presentation of the auditory stimulus. D-Amphetamine delayed tone habituation, whether administered systemically (0.5, 1 mg/kg) or into the nucleus accumbens shell (3, 10 microg/0.5 microl). These data are consistent with electrophysiological and neurochemical data demonstrating the role of nucleus accumbens dopamine in novelty processing. The relevance of the data to latent inhibition is discussed.