Abstract
Electrophysiological parameters of spontaneous cellular activity in the nucleus accumbens septi (NAS) and responses evoked by afferent (fimbria) stimulation were characterized in halothane-anesthetized rats. A heterogeneous pattern of cell activity and single cell responses to stimulation were observed throughout the NAS. Stimulation-evoked discharges from inactive cells regularly coincided with evoked ‘field’ responses. Because the NAS is critical for opiate drug self-administration in rats, the effects of systemic heroin and morphine were then observed. These drugs also had mixed effects on the spontaneous activity of NAS cells encountered. While most cells were depressed, other cells were excited or were unaffected. Opiates had no effect on stimulation-evoked activity. These data lend neurophysiological and neuropharmacological support to the neuroanatomical observations of cellular heterogeneity within this structure.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
