Abstract
Although Alzheimer's disease (AD) is considered a prototypical brain disease, extra-cerebral metabolic manifestations occur. On a clinical level, it is possible to demonstrate peripheral tissue insulin resistance. On a basic biochemical level, activity of the mitochondrial enzyme cytochrome oxidase is reduced in AD subject platelets and fibroblasts. Using mitochondria from AD subject platelets, we have generated neuronal-based cytoplasmic hybrid (cybrid) cell lines that facilitate studies of AD subject-derived mitochondria.
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