Abstract
IntroductionThe occurrence of systemic lupus erythematosus has been only rarely reported in patients with sickle-cell disease.Case presentationWe describe the case of a 23-year-old North-African woman with sickle-cell disease and systemic lupus erythematosus, and discuss the pointers to the diagnosis of this combination of conditions and also present a review of literature. The diagnosis of systemic lupus erythematosus was delayed because our patient’s symptoms were initially attributed to sickle-cell disease.ConclusionsPhysicians should be alerted to the possible association of sickle-cell disease and systemic lupus erythematosus so as not to delay correct diagnosis and initiation of appropriate treatment.
Highlights
The occurrence of systemic lupus erythematosus has been only rarely reported in patients with sickle-cell disease.Case presentation: We describe the case of a 23-year-old North-African woman with sickle-cell disease and systemic lupus erythematosus, and discuss the pointers to the diagnosis of this combination of conditions and present a review of literature
We report the case of a patient who developed symptoms initially attributed to Sickle-cell disease (SCD), but on further investigation underlying systemic lupus erythematosus (SLE) was revealed
Toly-Ndour et al reported that 50 percent of 88 patients with SCD had positive anti-nuclear antibody results and 20 percent had titers greater than one in 200, but only one patient developed rheumatoid arthritis five years later and no patients developed SLE [18]
Summary
Sickle-cell disease (SCD) is a prevalent genetic disorder that includes sickle-cell anemia (the homozygous and most common form of SCD (SS)), sickle-cell hemoglobin C (SC) and sickle-cell β thalassemia (S/β thal) [1]. The results of a bone scan showed diffuse bone infarcts Her symptoms were attributed to SCD and our patient received blood transfusions, antibiotics and analgesics, but with no improvement. Toly-Ndour et al reported that 50 percent of 88 patients with SCD had positive anti-nuclear antibody results and 20 percent had titers greater than one in 200, but only one patient developed rheumatoid arthritis five years later and no patients developed SLE [18]. In this series, patients treated with hydroxyurea had ANA-positive results less frequently than non-treated patients (P=0.053) [18].
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