Abstract
Systemic lupus erythematosus 2014.
Highlights
B lymphocytes are the effectors of humoral immunity, providing defense from pathogens through different functions including antibody production
Tobon and colleagues, who reviewed the functions of B lymphocytes in autoimmunity and autoimmune disease (AD) with a special focus on their abnormalities in SLE
Bonilla-Abadıa and colleagues report the results of a retrospective and descriptive observational study of patients with SLE refractory to conventional treatment who were treated with RTX as remission induction therapy and maintenance
Summary
B lymphocytes are the effectors of humoral immunity, providing defense from pathogens through different functions including antibody production. Nine papers were selected covering important topics of the disease from B lymphocytes (e.g., autoantibodies and B-cell depletion therapy), immunosenescence, and genetics to disease complications such as cardiovascular disease (CVD), preeclampsia, fatigue, and depression. In the context of ADs, B lymphocytes play an essential role by producing autoantibodies and functioning as antigen presenting cells and as a source of cytokines as pointed out by G.
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