Abstract
Hematologic disorders are very common in Systmic lupus erythematosus (SLE).First presentation of SLE with severe aplastic anemia (SAA) is extremely rare. We report a patient with the diagnosis of secondary SAA associated with SLE. Conventional therapy was not effective. She received Rituximab (RTX) and Antithymocyte globulin (ATG) therapy, her response was satisfactory finally. Her hematologic parameters were within normal ranges until last follow-up, eight months and six months after therapy was initiated with RTX and ATG, respectively. This is the first time RTX and ATG were successfully used in the treatment of SAA secondary to SLE.
Highlights
Systemic lupus erythematosus (SLE) is an autoimmune disease which affects multiple tissues and organs and is commonly seen in young women
Bone marrow aspiration and biopsy were performed for pancytopenia which showed less than 20% cellularity, megakaryocytes were absent and fatty change, suggestive for severe aplastic anemia (SAA)
Hematological complications are frequently seen in SLE, anaemia, leucopenia and thrombocytopenia always behind other manifestation of SLE
Summary
Systemic lupus erythematosus (SLE) is an autoimmune disease which affects multiple tissues and organs and is commonly seen in young women. Hematologic abnormalities are commonly associated with SLE.[1] Dysregulation of B lymphocyte cells plays a crucial role in the pathogenesis of the disease. Yuhong Zhou 1-5: Department of Hematology, First Clinical Medical School of Zhejiang Chinese Medicine University, China
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