Systemic inflammatory response syndrome and serious hepatitis

Abstract

Objective To investigate the incidence, clinical feature, survival rate(12 weeks) and the predictive factors of mortality in patients with systemic inflammatory response syndrome(SIRS) and serious hepatitis. Methods Through retrospective study over a period of 3 years(2005-2008), 141 clinical cases of serious hepatitis were discussed. 83 patients with SIRS served as SIRS group, others served as non-SIRS group. The clinical feature, complications, survival rate(12 weeks) and the predictive factors of mortality were investigated. Results In this study, the incidence of SIRS in serious hepatitis was 58.87% .There were statistical differences between the two grouos in the incidence of infection,hepatic encephalopathy, ascites and hepatorenal syndrome(P<0.01). The celiac and pulmonary infection were the main compli-cations of serious hepatitis with infection. The accumulative survival rate(12 weeks) were 22.9% and 55.2% respectively in two groups(P<0.01 ). Conclusions Tire incidence of SIRS is extremely higher in patients with serious hepatitis. SIRS is associated with the infection, hepatic encephalopathy, ascites and hepatorenal syndrome. The presence of SIRS is a major independent prognostic factor in patients with serious hepatitis. This suggests that preventing and treating SIRS could decrease the mortality in patients with serious hepatitis. Key words: Systemic inflammatory response syndrome; Serious hepatitis; Clinical study