Abstract
Introduction: Extensive soft tissue injury and bone fracture are significant contributors to the initial systemic inflammatory response in multiply injured patients. Systemic inflammation can lead to organ dysfunction remote from the site of traumatic injury. Mechanisms that activate the systemic inflammatory response to soft tissue and bone injury are unknown. Toll-like receptors (TLR) recognize microbial products but also may recognize danger signals released from damaged tissues. We hypothesized that peripheral tissue trauma generates release of danger signals that initiate systemic inflammation and remote organ injury and that this systemic response to a sterile local injury is Toll-like receptor 4 (TLR-4) dependent.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
